Supercritical Antisolvent Technique: Production of Nanoparticles

Supercritical antisolvent micronization (SAS) is a versatile technique that allows the obtainment of different morphologies and dimensions of precipitates, but only in some cases nanoparticles were produced. This work is focused on the selection of the SAS operating conditions to obtain this morphology. A series of experiments on several compounds and different solvents at 40 °C and selected pressure conditions, between 150 and 250 bar, were performed and nanoparticles with mean diameters ranging between 45 nm and 150 nm were obtained.